Quarterly report pursuant to Section 13 or 15(d)

Organization and Summary of Significant Accounting Policies (Details Narrative)

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Organization and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Jul. 28, 2017
Dec. 31, 2016
Dec. 31, 2015
Net loss $ 2,815 $ 4,338 $ 7,070 $ 12,790      
Net cash used in operating activities     4,396 5,257      
Accumulated deficit 220,206   $ 220,206     $ 213,135  
Debt instrument, payment terms     As discussed further in Note 7, in June 2014 the Company entered into a term loan with Hercules Technology Growth Capital, Inc. (“Hercules Technology”), as administrative and collateral agent for the lenders thereunder and as lender, and Hercules Technology III, LP, (“HT III” and, together with Hercules Technology, “Hercules”) as lender (the “Hercules Term Loan”). The Hercules Term Loan has a liquidity covenant that requires the Company to maintain a cash balance of the lesser of $2.5 million or the outstanding balance of the Hercules Term Loan. As of September 30, 2017, the outstanding balance on the Hercules Term Loan was $2.3 million and the Company’s cash balance was $2.8 million. The Company believes it will be in position to maintain compliance with the liquidity covenant related to the Hercules Term Loan at least through November 2017. On July 28, 2017, the Company entered into a $2.5 million term loan with a related party that will assist the Company in its cash needs through November 2017.        
Term loan principal balance         $ 2,500    
Cash and cash equivalents 2,816 $ 10,613 $ 2,816 $ 10,613   $ 6,915 $ 11,485
November 10, 2017 [Member]              
Reverse stock split     1 for 12 reverse stock        
Hercules Term Loan [Member]              
Term loan principal balance 2,300   $ 2,300        
Hercules Term Loan [Member] | Maximum [Member]              
Term loan principal balance $ 2,500   $ 2,500