Quarterly report pursuant to Section 13 or 15(d)

Organization and Summary of Significant Accounting Policies (Details Narrative)

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Organization and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Net loss $ 4,338 $ 10,133 $ 12,790 $ 21,447    
Net cash used in operating activities     5,257 7,065    
Accumulated deficit 209,327   $ 209,327   $ 196,537  
Debt instrument, payment terms     As discussed further in Note 7, in June 2014, the Company entered into a term loan with Hercules Technology Growth Capital, Inc. (“Hercules Technology”), as administrative and collateral agent for the lenders thereunder and as lender, and Hercules Technology III, LP, (“HT III” and, together with Hercules Technology, “Hercules”) as lender (the “Hercules Term Loan”). The Hercules Term Loan has a liquidity covenant that requires the Company to maintain a cash balance of not less than $3.5 million at September 30, 2016.      
Cash and cash equivalents 10,613 $ 11,268 $ 10,613 $ 11,268 $ 11,485 $ 18,247
Hercules Term Loan [Member] | Minimum [Member]            
Cash and cash equivalents $ 3,500   $ 3,500