Quarterly report pursuant to Section 13 or 15(d)

Organization and Summary of Significant Accounting Policies (Details Narrative)

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Organization and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Net loss $ 2,150 $ 3,388    
Net cash used in operating activities 1,833 1,465    
Accumulated deficit $ 215,285   $ 213,135  
Debt instrument, payment terms As discussed further in Note 7, in June 2014 the Company entered into a term loan with Hercules Technology Growth Capital, Inc. (“Hercules Technology”), as administrative and collateral agent for the lenders thereunder and as lender, and Hercules Technology III, LP, (“HT III” and, together with Hercules Technology, “Hercules”) as lender (the “Hercules Term Loan”). The Hercules Term Loan has a liquidity covenant that requires the Company to maintain a cash balance of not less than $2.5 million at March 31, 2017.      
Cash and cash equivalents $ 6,944 $ 7,943 $ 6,915 $ 11,485
July 28, 2017 [Member]        
Term loan principal balance 2,500      
Hercules Term Loan [Member] | Minimum [Member]        
Term loan principal balance $ 2,500